This product is an active protein and may elicit a biological response in vivo, handle with caution.
RAB1B member RAS oncogene family
Ras related protein Rab1B
Ras-related protein Rab-1B
Small GTP binding protein
FunctionProtein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.
Sequence similaritiesBelongs to the small GTPase superfamily. Rab family.
Post-translational modificationsPrenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1). AMPylation at Tyr-77 occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB1B constitutively active.
Cellular localizationMembrane. Cytoplasm. Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm.