Recombinant S. cerevisiae Glutaredoxin 2 protein (ab63232)

Overview

Description

  • NatureRecombinant
  • SourceSaccharomyces cerevisiae
  • Amino Acid Sequence
    • SpeciesSaccharomyces cerevisiae

Specifications

Our Abpromise guarantee covers the use of ab63232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

  • Purity> 90 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.01% Sodium Azide
    Constituents: 50% Glycerol, 1.5M Urea, 25mM Tris HCl, 1mM EDTA

General Info

  • Alternative names
    • bA101E13.1
    • bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2)
    • CGI133
    • Glrx2
    • GLRX2_HUMAN
    • Glutaredoxin-2
    • Glutaredoxin-2, mitochondrial
    • GRX2
    • mitochondrial
    see all
  • FunctionGlutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
  • Tissue specificityWidely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
  • Sequence similaritiesBelongs to the glutaredoxin family.
    Contains 1 glutaredoxin domain.
  • Cellular localizationMitochondrion and Nucleus.
  • Information by UniProt

References for Recombinant S. cerevisiae Glutaredoxin 2 protein (ab63232)

ab63232 has not yet been referenced specifically in any publications.

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