For the best experience on the Abcam website please upgrade to a modern browser such as
Source Escherichia coli
Amino Acid Sequence
Species Saccharomyces cerevisiae Specifications
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity > 90
Typical enzyme concentration to support conjugation in vitro is 50-200 nM depending on conditions.
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 50mM HEPES, 150mM Sodium chloride, pH 8.0
Anthracycline associated resistance ARX
Anthracycline-associated resistance ARX
Function The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Pathway Protein modification; protein sumoylation.
Sequence similarities Belongs to the ubiquitin-activating E1 family.
Cellular localization Nucleus.
Information by UniProt
References for Recombinant
S. cerevisiae SAE2 / UBA2 protein (ab80727)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"