This product is an active protein and may elicit a biological response in vivo, handle with caution.
thioredoxin 2 precursor
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1. Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
Recombinant S. cerevisiae Thioredoxin 2 protein images
SDS-PAGE - Thioredoxin 2 protein (Active) (ab82794)
SDS-PAGE showing ab82794 (1µg).
References for Recombinant S. cerevisiae Thioredoxin 2 protein (ab82794)
This product has been referenced in:
Brennan LA et al. TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of a-crystallin and cytochrome C in the eye lens. PLoS One5:e15421 (2010).
Read more (PubMed: 21079812) »