Recombinant S. cerevisiae Thioredoxin 2 protein (ab82794)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesSaccharomyces cerevisiae

Specifications

Our Abpromise guarantee covers the use of ab82794 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific activity : 9.7 U/mg. (One unit will cause a Delta A650 of 1.0 in 1 min at 25°C in the insulin reduction assay).
  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 20mM HEPES, pH 7.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • mitochondrial thioredoxin
    • MT-TRX
    • MTRX
    • thioredoxin 2 precursor
    • Thioredoxin mitochondrial
    • Thioredoxin2
    • TRX 2
    • TRX2
    • TXN 2
    • TXN2
    see all
  • RelevanceThioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1. Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
  • Cellular localizationMitochondrial

Recombinant S. cerevisiae Thioredoxin 2 protein images

  • SDS-PAGE showing ab82794 (1µg).

References for Recombinant S. cerevisiae Thioredoxin 2 protein (ab82794)

This product has been referenced in:
  • Brennan LA  et al. TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of a-crystallin and cytochrome C in the eye lens. PLoS One 5:e15421 (2010). Read more (PubMed: 21079812) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"