The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. Purity >98% (HPLC)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Reconstitutionreconstitute with 0.1ml water.
Maxi K channel
Potassium large conductance calcium-activated channel
RelevanceSlotoxin is a peptide from Centruroides noxius Hoffmann scorpion venom. It belongs to the short scorpion toxin superfamily.
The 37 amino acid peptide belongs to the charybdotoxin sub-family (alphaKTx1) and was numbered member 11. alphaKTx1.11 revealed specificity for mammalian MaxiK channels (hSlo), thus, was named slotoxin.
Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha-subunits (Kd = 1.5 nM). Unreversibly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta1-subunits. Unreversibly and weakly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta4-subunits. It shows no activity on other potassium channels.
References for Recombinant Slotoxin protein (ab54262)
has not yet been referenced specifically in any publications.
Publishing research using ab54262? Please let us know so that we can cite the reference in this datasheet.
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