Overview

  • Product nameRecombinant Slotoxin protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SequenceThr-Phe-Ile-Asp-Val-Asp-Cys-Thr-Val-Ser-Lys-Glu-Cy s-Trp-Ala-Pro-Cys-Lys-Ala-Ala-Phe-Gly-Val-Asp-Arg- Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Lys-Cys-Tyr-Val

Specifications

Our Abpromise guarantee covers the use of ab54262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity> 95 % SDS-PAGE.
    Purity >98% (HPLC)
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitutionreconstitute with 0.1ml water.

General Info

  • Alternative names
    • BKCA alpha
    • KCNMA1
    • Maxi K channel
    • Potassium large conductance calcium-activated channel
    • SLO ALPHA
    • Slowpoke homolog
    see all
  • RelevanceSlotoxin is a peptide from Centruroides noxius Hoffmann scorpion venom. It belongs to the short scorpion toxin superfamily. The 37 amino acid peptide belongs to the charybdotoxin sub-family (alphaKTx1) and was numbered member 11. alphaKTx1.11 revealed specificity for mammalian MaxiK channels (hSlo), thus, was named slotoxin. Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha-subunits (Kd = 1.5 nM). Unreversibly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta1-subunits. Unreversibly and weakly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta4-subunits. It shows no activity on other potassium channels.

References for Recombinant Slotoxin protein (ab54262)

ab54262 has not yet been referenced specifically in any publications.

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