Recombinant Staphylokinase protein (ab73828)

Overview

  • Product name
    Recombinant Staphylokinase protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Dermatophagoides farinae
    • Sequence
      The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Ser-Ser-Phe-Asp.

Specifications

Our Abpromise guarantee covers the use of ab73828 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    The biological activity is measured by the ability of fibrin lysis in agarose plate was found to be 4600 IU/mg.
  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    Purified by proprietary chromatographic techniques. Purity: Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20mM PBS, pH 7

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute the lyophilized product in sterile 18MOhm-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

General Info

  • Alternative names
    • Neutral proteinase
    • Protease III
    • SAK
    • SakSTAR
  • Relevance
    Staphylokinase (SAK) is a 136-amino acid enzyme from Staphylococcus aureus. It is positively regulated by the "agr" gene regulator. It activates plasminogen to form plasmin, which digest fibrin clots. This disrupts the fibrin meshwork which can often form to keep an infection localized. Staphylokinase also cleaves IgG and complement component C3b, inhibiting phagocytosis.
  • Cellular localization
    Secreted

References

ab73828 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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