The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological Activity : Determined by its ability to inhibit apoptosis induced by Human sTRAIL/Apo2L in LN-18 cells (human glioblastoma cells).
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
ReconstitutionRECONSTITUTE IN WATER TO A CONCENTRATION OF 1 MG/ML
Apoptosis inducing protein TRICK2A 2B
Apoptosis inducing protein TRICK2A/2B
Apoptosis inducing receptor TRAIL R2
Cytotoxic TRAIL receptor 2
Death domain containing receptor for TRAIL Apo 2L
Death receptor 5
Fas like protein
p53 regulated DNA damage inducible cell death receptor killer
p53 regulated DNA damage inducible cell death receptor(killer)
TNF receptor superfamily member 10b
TNF related apoptosis inducing ligand receptor 2
TNF-related apoptosis-inducing ligand receptor 2
TRAIL receptor 2
Tumor necrosis factor receptor like protein ZTNFR9
Tumor necrosis factor receptor superfamily member 10B
Tumor necrosis factor receptor superfamily, member 10b
FunctionReceptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Tissue specificityWidely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Involvement in diseaseSquamous cell carcinoma of the head and neck
Sequence similaritiesContains 1 death domain. Contains 3 TNFR-Cys repeats.