Recombinant Treponema Membrane Protein A (ab68126)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli

Specifications

Our Abpromise guarantee covers the use of ab68126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    ab68126 is immunoreactive with sera of Treponema Pallidum infected individuals. This protein binds to murine anti-TmpA protein monoclonal antibodies and Treponema pallidum converted human serum polyclonal antibodies in ELISA and Western Blot.
  • Applications

    SDS-PAGE

    Western blot

    ELISA

    Dot blot

  • Purity
    > 95 % SDS-PAGE.
    ab68126 is purified by a proprietary chromatographic technique.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 8M Urea, 20mM DTT, 10mM Tris HCl, 1mM EDTA, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Antigen tmpA
    • Membrane protein A
    • tmpA
  • Relevance
    Treponema pallidum is a gram-negative spirochaete bacterium and is considered to be metabolically crippled. There is no vaccine for syphilis. The outer membrane of T. pallidum has too few surface proteins for an antibody to be effective. Efforts to develop a safe and effective syphilis vaccine have been hindered by uncertainty about the relative importance of humoral and cellular mechanisms to protective immunity and the fact that T. pallidum outer membrane proteins have not been unambiguously identified.
  • Cellular localization
    Cell Membrane

References

ab68126 has not yet been referenced specifically in any publications.

Publishing research using ab68126? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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