Overview

  • Product name
    Anti-Red Blood Cells antibody [34-3C]
    See all Red Blood Cells primary antibodies
  • Description
    Mouse monoclonal [34-3C] to Red Blood Cells
  • Specificity
    Recognizes an exposed surface determinant of intact Red Blood Cells. ab106101 only recognises antigenic determinants expressed on Mouse RBC and not on other species of RBC.
  • Tested applications
    Suitable for: Functional Studies, Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
    Does not react with: Rat, Sheep, Rabbit, Chicken, Human
  • Immunogen

    Mouse Red Blood Cells

  • Positive control
    • Mouse erythrocytes
  • General notes


    This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 0.1% BSA, PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    0.2 µm filtered solution
  • Primary antibody notes
    This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.
  • Clonality
    Monoclonal
  • Clone number
    34-3C
  • Isotype
    IgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.
Flow Cyt 1/50. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • Relevance
    Red blood cells are the most common type of blood cell and are the vertebrate body's principal means of delivering oxygen from the lungs or gills to body tissues via the blood.
  • Alternative names
    • Erythrocytes antibody
    • RBCs antibody

References

This product has been referenced in:
  • Baudino L  et al. Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J Immunol 180:1948-53 (2008). Read more (PubMed: 18209093) »
  • Azeredo da Silveira S  et al. Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med 195:665-72 (2002). Read more (PubMed: 11901193) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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