Overview

  • Product name
    Anti-REEP1 antibody
  • Description
    Rabbit polyclonal to REEP1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 110-159 (AKDRSYDALV HFGKRGLNVA ATAAVMAASK GQGALSERLR SFSMQDLTTI) of Human REEP1 (NP_075063).

  • Positive control
    • Human fetal brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab105583 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    May enhance the cell surface expression of odorant receptors.
  • Involvement in disease
    Defects in REEP1 are the cause of spastic paraplegia autosomal dominant type 31 (SPG31) [MIM:610250]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
  • Sequence similarities
    Belongs to the DP1 family.
  • Cellular localization
    Mitochondrion membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C2orf23 antibody
    • Chromosome 2 open reading frame 23 antibody
    • FLJ13110 antibody
    • Receptor accessory protein 1 antibody
    • Receptor expression-enhancing protein 1 antibody
    • Reep1 antibody
    • REEP1_HUMAN antibody
    • SPG31 antibody
    see all

Images

  • Anti-REEP1 antibody (ab105583) at 1 µg/ml + Human fetal brain lysate at 10 µg

    Predicted band size : 22 kDa

References

This product has been referenced in:
  • Garcia-Esparcia P  et al. Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain. J Neuropathol Exp Neurol 72:524-39 (2013). Read more (PubMed: 23656994) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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