Overview

  • Product name
  • Description
    Rabbit polyclonal to Reg3a
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH selected from the N terminal region of Human Reg3a (NP_002571.1)

  • Positive control
    • 293 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab95316 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab95316 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 19 kDa.

Target

  • Function
    Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
  • Tissue specificity
    Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
  • Sequence similarities
    Contains 1 C-type lectin domain.
  • Domain
    The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
  • Post-translational
    modifications
    Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
  • Cellular localization
    Secreted. Found in the apical region of pancreatic acinar cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ18565 antibody
    • Hepatocarcinoma intestine pancreas antibody
    • Hepatointestinal pancreatic protein antibody
    • HIP antibody
    • HIP/PAP antibody
    • Human proislet peptide antibody
    • INGAP antibody
    • Pancreatic beta cell growth factor antibody
    • Pancreatitis associated protein 1 antibody
    • Pancreatitis associated protein antibody
    • Pancreatitis-associated protein 1 antibody
    • PAP antibody
    • PAP H antibody
    • PAP homologous protein antibody
    • PAP1 antibody
    • PBCGF antibody
    • Proliferation inducing protein 34 antibody
    • Proliferation inducing protein 42 antibody
    • Reg III alpha antibody
    • REG III antibody
    • Reg III-alpha antibody
    • REG-3-alpha antibody
    • REG3 antibody
    • Reg3a antibody
    • REG3A_HUMAN antibody
    • Regenerating islet derived 3 alpha antibody
    • Regenerating islet derived protein 3 alpha precursor antibody
    • Regenerating islet-derived protein 3-alpha 15 kDa form antibody
    • Regenerating islet-derived protein III-alpha antibody
    see all

Anti-Reg3a antibody images

  • Anti-Reg3a antibody (ab95316) at 1/100 dilution (in TTBS/1% NFDM for 1 hr. at room temperature) + 293 cell line lysate at 35 µg

    Secondary
    Enzyme-linked secondary antibody (typically horseradish peroxidase or alkaline phosphatase) in TTBS/1% NFDM for 30 min. at room temperature.

    Predicted band size : 19 kDa

References for Anti-Reg3a antibody (ab95316)

ab95316 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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