Anti-Reptin/TIP49B/RUVB2 antibody (ab109872)

Overview

  • Product nameAnti-Reptin/TIP49B/RUVB2 antibody
    See all Reptin/TIP49B/RUVB2 primary antibodies
  • Description
    Rabbit polyclonal to Reptin/TIP49B/RUVB2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant protein (Human)

  • Positive control
    • WB: A431 or H1299 cell lysate. IHC-P: skin, testis, or uterus tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab109872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 51 kDa.
IHC-P Use a concentration of 10 µg/ml.

Target

  • FunctionPossesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.
  • Tissue specificityUbiquitously expressed. Highly expressed in testis and thymus.
  • Sequence similaritiesBelongs to the ruvB family.
  • DomainThe C-terminal domain is required for association with ATF2.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus matrix. Nucleus > nucleoplasm. Cytoplasm. Membrane. Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes.
  • Information by UniProt
  • Database links
  • Alternative names
    • 48 kDa TATA box-binding protein-interacting protein antibody
    • 48 kDa TBP-interacting protein antibody
    • 48-kDa TATA box-binding protein-interacting protein antibody
    • 48-kDa TBP-interacting protein antibody
    • 51 kDa erythrocyte cytosolic protein antibody
    • CGI-46 antibody
    • EC=3.6.1.- antibody
    • ECP-51 antibody
    • ECP51 antibody
    • Erythrocyte cytosolic protein, 51-KD antibody
    • INO80 complex subunit J antibody
    • INO80J antibody
    • MGC144733 antibody
    • MGC144734 antibody
    • MGC52995 antibody
    • mp47 antibody
    • p47 antibody
    • p47 protein antibody
    • Repressing pontin 52 antibody
    • Reptin 52 antibody
    • REPTIN antibody
    • RuvB (E coli homolog)-like 2 antibody
    • RUVB, E. coli, homolog-like 2 antibody
    • RuvB-like 2 (E. coli) antibody
    • RuvB-like 2 antibody
    • RuvB-like protein 2 antibody
    • RUVB2 antibody
    • RUVB2_HUMAN antibody
    • RUVBL2 antibody
    • RVB2 antibody
    • TAP54-beta antibody
    • TATA box-binding protein-interacting protein, 48-KD antibody
    • TBP-interacting protein, 48-KD antibody
    • TIH2 antibody
    • TIP48 antibody
    • TIP49b antibody
    • TIP60-associated protein 54-beta antibody
    • wu:fi25f01 antibody
    • zreptin antibody
    see all

Anti-Reptin/TIP49B/RUVB2 antibody images

  • All lanes : Anti-Reptin/TIP49B/RUVB2 antibody (ab109872) at 1/5000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : H1299 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 51 kDa
  • ab109872 at 10 µg/ml staining formalin-fixed, paraffin-embedded Human skin tissue.
  • ab109872 at 10 µg/ml staining formalin-fixed, paraffin-embedded Human testis tissue.
  • ab109872 at 10 µg/ml staining formalin-fixed, paraffin-embedded Human uterus tissue.

References for Anti-Reptin/TIP49B/RUVB2 antibody (ab109872)

ab109872 has not yet been referenced specifically in any publications.

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