The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
Use at an assay dependent concentration. ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
1/1000. Detects a band of approximately 50, 37, 45, 74, 100 kDa (predicted molecular weight: 50, 37 kDa).
RelevanceMutations in Repulsive Guidance Molecule (also known as RGM-C; HJV; hemojuvelin; Hfe2) cause juvenile hemochromatosis, a severe iron overload disease. RGM-C gene expression has been characterized in the developing mouse and found to be exclusively expressed in all striated muscle and in the myocardium.
References for Anti-Repulsive Guidance Molecule C antibody [Fery-1] (ab54431)
This product has been referenced in:
van Swelm RP et al. Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis. Toxicol Sci129:225-33 (2012).
Read more (PubMed: 22610607) »
Lakhal S et al. Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors: NEW LINK BETWEEN HYPOXIA SIGNALING AND IRON HOMEOSTASIS. J Biol Chem286:4090-7 (2011).
Read more (PubMed: 20966077) »