The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Dot: Use at an assay dependent dilution.
ICC/IF: 1/100 (PMID 19131340).
WB: Use at an assay dependent dilution. Predicted molecular weight: 172 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
Widely expressed. Expressed in tumor cell lines.
Involvement in disease
Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line. Translocation t(1;15)(p36.2;q24).
Hou R & Sibinga NE Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells. J Biol Chem284:6955-65 (2009).
Read more (PubMed: 19131340) »