Reacts with Respiratory Syncytial Virus.
Does not react with tissue culture isolates of influenza types A and B, parainfluenza types 1, 2, 3, and 4b, adenovirus, HSV types 1 and 2, VZV, cytomegalovirus, mumps and measles virus, coxsackie B4 virus, poliovirus types 1,2 and 3, or ECHOvirus 19.
Native Respiratory Syncytial Virus, strain A2.
IHC-P: RSV infected lung. Stains RSV infected epithelial cell membranes and cytoplasm.
IF: Acetone fixed RSV-A2 infected HeLa cells.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/5 - 1/20. Fix with acetone.
1/50 - 1/400. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
RelevanceRespiratory syncytial virus (RSV) is a major cause of respiratory illness in young children. RSV infection produces a variety of signs and symptoms involving different areas of the respiratory tract, from the nose to the lungs. RSV is a negative sense, enveloped RNA virus. The virion is variable in shape and size with average diameter of between 120 and 300 nm. The 63 kD RSV fusion protein of the RSS 2 strain (subtype A) directs fusion of viral and cellular membranes, results in viral penetration, and can direct fusion of infected cells with adjoining cells, resulting in the formation of syncytia or multi nucleated giant cells.
Cellular localizationVirion. Host cytoplasm
RS virus antibody
References for Anti-Respiratory Syncytial Virus antibody [4 clone blend] (ab35958)
This product has been referenced in:
Cagno V et al. Highly sulfated K5 Escherichia coli polysaccharide derivatives inhibit respiratory syncytial virus infectivity in cell lines and human tracheal-bronchial histocultures. Antimicrob Agents Chemother58:4782-94 (2014).
Read more (PubMed: 24914125) »
Donalisio M et al. Inhibition of human respiratory syncytial virus infectivity by a dendrimeric heparan sulfate-binding peptide. Antimicrob Agents Chemother56:5278-88 (2012).
Read more (PubMed: 22850525) »