Anti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133] (ab94966)

Overview

  • Product nameAnti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133]
  • Description
    Mouse monoclonal [RSV133] to Respiratory Syncytial Virus G Glycoprotein
  • Tested applicationsSuitable for: ELISA, WB, ICC/IF, IHC-Frmore details
  • Species reactivity
    Reacts with: Other
  • Immunogen

    Human Respiratory Syncytial Virus strain A2 infected HeLa cells

  • General notesFusion partner: PS-NS/1-Ag4


    ab94966 is useful for the identification and location of expression of the G glycoprotein of Human Respiratory Syncytial Virus (HRSV) of both sub-groups A and B . This antibody confers passive protection against HRSV of both subgroups in an animal model of hRSV infection.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein A purified
  • Primary antibody notesab94966 is useful for the identification and location of expression of the G glycoprotein of Human Respiratory Syncytial Virus (HRSV) of both sub-groups A and B . This antibody confers passive protection against HRSV of both subgroups in an animal model of hRSV infection.
  • ClonalityMonoclonal
  • Clone numberRSV133
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab94966 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 33 kDa.
ICC/IF Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration. Fix with Acetone.

Target

  • RelevanceRespiratory Syncytial Virus (RSV) G Glycoprotein attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. It interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, it lacks both neuraminidase and hemagglutinating activities.
  • Cellular localizationVirion membrane. Host cell surface
  • Alternative names
    • Attachment glycoprotein G antibody
    • G antibody
    • Major surface glycoprotein G antibody
    • Membrane bound glycoprotein antibody
    • mG antibody
    • RSV G Glycoprotein antibody
    see all

References for Anti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133] (ab94966)

This product has been referenced in:
  • Le Nouën C  et al. Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization. Proc Natl Acad Sci U S A 111:13169-74 (2014). Read more (PubMed: 25157129) »

See 1 Publication for this product

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I was trying to find the source of the statement: "This antibody confers passive protection against HRSV of both subgroups in an animal model of hRSV infec...

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We used Human RSV strain A2 infected HeLa cells to raise this antibody. The exact epitope sequence has not been determined so I am sorry we do not have, any extra information, other than what is already on the datashee...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"