Anti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133] (ab94966)

Overview

  • Product name
    Anti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133]
  • Description
    Mouse monoclonal [RSV133] to Respiratory Syncytial Virus G Glycoprotein
  • Tested applications
    Suitable for: ELISA, WB, ICC/IF, IHC-Frmore details
  • Species reactivity
    Reacts with: Other
  • Immunogen

    Human Respiratory Syncytial Virus strain A2 infected HeLa cells

  • General notes
    Fusion partner: PS-NS/1-Ag4


    ab94966 is useful for the identification and location of expression of the G glycoprotein of Human Respiratory Syncytial Virus (HRSV) of both sub-groups A and B . This antibody confers passive protection against HRSV of both subgroups in an animal model of hRSV infection.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Primary antibody notes
    ab94966 is useful for the identification and location of expression of the G glycoprotein of Human Respiratory Syncytial Virus (HRSV) of both sub-groups A and B . This antibody confers passive protection against HRSV of both subgroups in an animal model of hRSV infection.
  • Clonality
    Monoclonal
  • Clone number
    RSV133
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab94966 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 33 kDa.
ICC/IF Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration. Fix with Acetone.

Target

  • Relevance
    Respiratory Syncytial Virus (RSV) G Glycoprotein attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. It interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, it lacks both neuraminidase and hemagglutinating activities.
  • Cellular localization
    Virion membrane. Host cell surface
  • Alternative names
    • Attachment glycoprotein G antibody
    • G antibody
    • Major surface glycoprotein G antibody
    • Membrane bound glycoprotein antibody
    • mG antibody
    • RSV G Glycoprotein antibody
    see all

References for Anti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133] (ab94966)

This product has been referenced in:
  • Shi H  et al. Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice. Sci Rep 6:35851 (2016). Read more (PubMed: 27767097) »
  • Le Nouën C  et al. Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization. Proc Natl Acad Sci U S A 111:13169-74 (2014). Read more (PubMed: 25157129) »

See all 2 Publications for this product

Product Wall

Thank you for your inquiry.

I am very sorry for the delay in my answer.

I was trying to find the source of the statement: "This antibody confers passive protection against HRSV of both subgroups in an animal model of hRSV infec...

Read More

Thank you for contacting us.
We used Human RSV strain A2 infected HeLa cells to raise this antibody. The exact epitope sequence has not been determined so I am sorry we do not have, any extra information, other than what is already on the datashee...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up