• Product name
    Anti-Retinal protein 4 antibody
    See all Retinal protein 4 primary antibodies
  • Description
    Mouse polyclonal to Retinal protein 4
  • Host species
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog
  • Immunogen

    Full length protein, corresponding to amino acids 1-240 of Human Retinal protein 4, Isoform A (NP_005139.1, UniProt ID: Q13432-1)

  • Positive control
    • Lysate from 293T cells transfected with Retinal protein 4; HeLa cells.


  • Form
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.20
    Constituent: 100% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab169652 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa.
ICC/IF Use a concentration of 10 µg/ml.


  • Function
    Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Binds myristoylated NPHP3; however, in contrast to UNC119B, does not seem to play a major role in ciliary membrane localization of NPHP3. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.
  • Tissue specificity
    Retinal-specific. Localized in photoreceptor synapses in the outer plexiform layer of the retina.
  • Involvement in disease
    Note=Defects in UNC119 may be a cause of cone-rod dystrophy. A mutation was found in a 57-year-old woman with late-onset cone-rod dystrophy: from 40 year old, the patient suffered from poor night vision, defective color vision and light-sensitivity. At 57 year old, she displayed reduced visual acuity, myopa, macular atrophy and pericentral ring scotomas. The disease was caused by a heterozygous mutation causing premature termination and truncated UNC119 protein with dominant-negative effect.
  • Sequence similarities
    Belongs to the PDE6D/unc-119 family.
  • Domain
    Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides (PubMed:21642972). Phe residues within the hydrophobic beta sandwich are required for myristate binding (PubMed:22085962).
  • Cellular localization
    Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cone-rod dystrophy, included antibody
    • hRG4 antibody
    • Human retinal gene 4 antibody
    • MRG4 antibody
    • POC7 antibody
    • POC7 centriolar protein homolog A antibody
    • POC7A antibody
    • Protein unc 119 homolog A antibody
    • Protein unc-119 homolog A antibody
    • Retinal protein 4 antibody
    • RG4 antibody
    • RRG4 antibody
    • Rtg4 antibody
    • U119A_HUMAN antibody
    • unc 119 homolog (C. elegans) antibody
    • Unc 119 protein homolog antibody
    • unc119 (C.elegans) homolog antibody
    • UNC119 antibody
    • Unc119h antibody
    • Uncl19 antibody
    see all


  • All lanes : Anti-Retinal protein 4 antibody (ab169652) at 1 µg/ml

    Lane 1 : Retinal protein 4-transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Developed using the ECL technique.

    Predicted band size: 27 kDa

  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, labeling Retinal protein 4 using ab169652 at 10 µg/ml.


ab169652 has not yet been referenced specifically in any publications.

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