Recombinant
RabMAb

Anti-Retinoic Acid Receptor gamma antibody [EPR15901] - N-terminal (ab192608)

Overview

  • Product name
    Anti-Retinoic Acid Receptor gamma antibody [EPR15901] - N-terminal
    See all Retinoic Acid Receptor gamma primary antibodies
  • Description
    Rabbit monoclonal [EPR15901] to Retinoic Acid Receptor gamma - N-terminal
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Recombinant fragment within Human Retinoic Acid Receptor gamma aa 1-150 (N terminal). The exact sequence is proprietary.
    Database link: P13631

  • Positive control
    • BxPC3 and HeLa cell lysates; HACAT cells.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab192608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).
ICC/IF 1/100.

Target

  • Function
    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Domain
    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • NR1B3 antibody
    • Nuclear receptor subfamily 1 group B member 3 antibody
    • RAR gamma antibody
    • RAR-gamma antibody
    • RARC antibody
    • Rarg antibody
    • RARG_HUMAN antibody
    • Retinoic acid receptor gamma 2 antibody
    • Retinoic acid receptor gamma antibody
    • Retinoic acid receptor, gamma antibody
    see all

Images

  • All lanes : Anti-Retinoic Acid Receptor gamma antibody [EPR15901] - N-terminal (ab192608) at 1/5000 dilution

    Lane 1 : BxPC3 cell lysate
    Lane 2 : HeLa cell lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

    Predicted band size : 50 kDa
  • Immunofluorescent analysis of HACAT cells (4% Paraformaldehyde-fixed, 0.1% tritonX-100 permeabilized) labeling Retinoic Acid Receptor gamma with ab192608 at 1/100 dilution (4.6 μg/ml) followed by Goat anti rabbit IgG (Alexa Fluor® 488) (ab150077) at 1/400 dilution.  Counterstained wtih DAPI.

References

ab192608 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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