Anti-REV1 antibody (ab5088)

Overview

• Product name
  Anti-REV1 antibody
  See all REV1 primary antibodies
• Description
  Goat polyclonal to REV1
• Tested applications
  Suitable for: ICCmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Cow, Dog
• Immunogen

  Synthetic peptide:

  VLQQTYGSTLKVT

  , corresponding to amino acids 1239-1251 of Human REV 1L.

  Run BLAST with Run BLAST with
• General notes

  
  

  REV1L is the human homolog of the S. cerevisiae mutagenesis protein Rev1. The REV1 protein is conserved from yeast to humans. All REV1 proteins contain a BRCT domain, which is important in protein-protein interactions.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage buffer
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris-saline. pH 7.3
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Purification notes
  Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Primary antibody notes
  REV1L is the human homolog of the S. cerevisiae mutagenesis protein Rev1. The REV1 protein is conserved from yeast to humans. All REV1 proteins contain a BRCT domain, which is important in protein-protein interactions.
• Clonality
  Polyclonal
• Isotype
  IgG2c
• Research areas
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • DNA Damage Response
  • BRCT Domain Proteins

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Synthesis
  • Translesion Synthesis

Associated products

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
• Positive Controls
  • MOLT4 whole cell lysate (ab7912)

Applications

Target

• Function
  Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
• Tissue specificity
  Ubiquitous.
• Sequence similarities
  Belongs to the DNA polymerase type-Y family.
  Contains 1 BRCT domain.
  Contains 1 umuC domain.
• Domain
  The C-terminal domain is necessary for protein interactions.
• Cellular localization
  Nucleus.

• Target information above from: UniProt accession Q9UBZ9 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 51455 Human
  • Entrez Gene: 56210 Mouse
  • Entrez Gene: 316344 Rat
  • GenBank: NP_057400 Human
  • Omim: 606134 Human
  • SwissProt: Q9UBZ9 Human
  • SwissProt: Q920Q2 Mouse
  • Unigene: 443077 Human

  • Unigene: 260943 Mouse
  • Unigene: 389103 Mouse

  see all
• Alternative names
  • AIBP 80 antibody
  • AIBP80 antibody
  • Alpha integrin binding protein 80 antibody

  • Alpha integrin-binding protein 80 antibody
  • DNA repair protein REV 1 antibody
  • DNA repair protein REV1 antibody
  • FLJ21523 antibody
  • MGC163283 antibody
  • MGC26225 antibody
  • REV 1 (yeast homolog) like antibody
  • REV 1 antibody
  • REV 1 homolog antibody
  • REV 1 like antibody
  • REV 1 protein antibody
  • REV 1L antibody
  • REV1 (yeast homolog) like antibody
  • REV1 antibody
  • REV1 homolog (S. cerevisiae) antibody
  • REV1 homolog antibody
  • REV1 like (yeast) antibody
  • REV1 like antibody
  • Rev1 like terminal deoxycytidyl transferase antibody
  • REV1 protein antibody
  • Rev1-like terminal deoxycytidyl transferase antibody
  • REV1_HUMAN antibody
  • REV1L antibody

  see all

Protocols

• Immunocytochemistry & immunofluorescence protocols