Overview

  • Product name
  • Description
    Rabbit polyclonal to Rffl
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 61-312 of Human Rffl (UniProt: Q8WZ73).

  • Positive control
    • U-87 MG and Mouse liver whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab151488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 41 kDa.

Target

  • Function
    Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
  • Tissue specificity
    Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 FYVE-type zinc finger.
    Contains 1 RING-type zinc finger.
    Contains 2 SAP domains.
  • Post-translational
    modifications
    Rapidly degraded after stimulation with TNFSF10, probably by caspases.
    Auto-ubiquitinated (in vitro).
    Palmitoylated.
  • Cellular localization
    Cytoplasm. Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CARP-2 antibody
    • CARP2 antibody
    • Caspase regulator CARP2 antibody
    • Caspases 8 and 10 associated RING finger protein 2 antibody
    • caspases-8 and -10- associated RING finger protein 2 antibody
    • Caspases-8 and -10-associated RING finger protein 2 antibody
    • E3 ubiquitin protein ligase rififylin antibody
    • E3 ubiquitin-protein ligase rififylin antibody
    • Fring antibody
    • FYVE RING finger protein Sakura antibody
    • FYVE-RING finger protein Sakura antibody
    • Rffl antibody
    • RFFL_HUMAN antibody
    • Rififylin antibody
    • RING finger and FYVE like domain containing protein antibody
    • RING finger and FYVE-like domain-containing protein 1 antibody
    • RING finger protein 189 antibody
    • RING finger protein 34 like antibody
    • RING finger protein 34-like antibody
    • RNF189 antibody
    • RNF34L antibody
    see all

Images

  • Anti-Rffl antibody (ab151488) at 1/1000 dilution + U-87 MG whole cell lysate at 30 µg

    Predicted band size : 41 kDa
  • Anti-Rffl antibody (ab151488) at 1/1000 dilution + Mouse liver whole cell lysate at 50 µg

    Predicted band size : 41 kDa

References

ab151488 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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