Overview

  • Product nameAnti-RFX3 antibody
    See all RFX3 primary antibodies
  • Description
    Rabbit polyclonal to RFX3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 660-690 of Human RFX3 (NP_602304.1, NP_002910.1).

  • Positive control
    • MDA-MB435 cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab112962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 84 kDa.

Target

  • FunctionTranscription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Acts as a transcription factor. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.
  • Sequence similaritiesBelongs to the RFX family.
    Contains 1 H-T-H motif winged-type DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA32F11.1 antibody
    • DNA binding protein RFX3 antibody
    • Regulatory factor X 3 antibody
    • Regulatory factor X, 3 (influences HLA class II expression) antibody
    • RFX3 antibody
    • RFX3_HUMAN antibody
    • Transcription factor RFX3 antibody
    see all

Anti-RFX3 antibody images

  • Anti-RFX3 antibody (ab112962) at 1/100 dilution + MDA-MB435 cell line lysate at 35 µg

    Predicted band size : 84 kDa

References for Anti-RFX3 antibody (ab112962)

ab112962 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"