Overview

  • Product nameAnti-RFX5 antibody
    See all RFX5 primary antibodies
  • Description
    Mouse monoclonal to RFX5
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 516-617 of Human RFX5

Properties

Applications

Our Abpromise guarantee covers the use of ab57920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActivates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
    • Tissue specificityUbiquitous.
    • Involvement in diseaseDefects in RFX5 are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
    • Sequence similaritiesBelongs to the RFX family.
      Contains 1 RFX-type winged-helix DNA-binding domain.
    • DomainThe N-terminus is required for dimer formation, association with RFXANK and RFXAP, assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y.
    • Post-translational
      modifications
      Phosphorylated.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • DNA binding protein RFX 5 antibody
      • DNA binding protein RFX5 antibody
      • DNA-binding protein RFX5 antibody
      • Influences HLA class II expression antibody
      • Regulatory factor X 5 antibody
      • Regulatory factor X subunit 5 antibody
      • Regulatory factor X, 5 (influences HLA class II expression) antibody
      • RFX 5 antibody
      • RFX5 antibody
      • Rfx5 protein antibody
      • RFX5_HUMAN antibody
      see all

    Anti-RFX5 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57920 RFX5 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-RFX5 antibody (ab57920)

    ab57920 has not yet been referenced specifically in any publications.

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