Overview

  • Product nameAnti-RFXANK antibody
    See all RFXANK primary antibodies
  • Description
    Rabbit polyclonal to RFXANK
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 93-123 of Human RFXANK (NP_604389.1, NP_003712.1).

  • Positive control
    • WiDr cell line lysates

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab124068 is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab124068 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 28 kDa.

Target

  • FunctionActivates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
  • Tissue specificityUbiquitous.
  • Involvement in diseaseDefects in RFXANK are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
  • Sequence similaritiesContains 5 ANK repeats.
  • DomainThe third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANKRA1 antibody
    • Ankyrin repeat containing regulatory factor X associated protein antibody
    • Ankyrin repeat family A protein 1 antibody
    • BLS antibody
    • DNA-binding protein RFXANK antibody
    • F14150_1 antibody
    • MGC138628 antibody
    • Regulatory factor X associated ankyrin containing protein antibody
    • Regulatory factor X subunit B antibody
    • Regulatory factor X, ankyrin repeat containing antibody
    • Regulatory factor X-associated ankyrin-containing protein antibody
    • RFX Bdelta4 antibody
    • RFX-B antibody
    • RFXANK antibody
    • RFXB antibody
    • RFXB delta 4 antibody
    • RFXK_HUMAN antibody
    see all

Anti-RFXANK antibody images

  • Anti-RFXANK antibody (ab124068) at 1/100 dilution + WiDr cell line lysates at 35 µg

    Predicted band size : 28 kDa

References for Anti-RFXANK antibody (ab124068)

ab124068 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"