Anti-RFXAP antibody [RFXAD55A] (ab51376)

Overview

• Product nameAnti-RFXAP antibody [RFXAD55A]
  See all RFXAP primary antibodies
• Description
  Mouse monoclonal [RFXAD55A] to RFXAP
• Tested applicationsSuitable for: Dot blot, ELISA, WBmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant fragment, corresponding to internal sequence amino acids 50-200 of Human RFXAP

• Positive control
  • HeLa whole cell lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
• Storage bufferPreservative: 0.05% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• PurityProtein G purified
• Purification notesFiltered through a 0.22 µm membrane.
• ClonalityMonoclonal
• Clone numberRFXAD55A
• IsotypeIgG1
• Research areas
  • Immunology
  • Adaptive Immunity
  • MHC
  • Class II

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

Associated products

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
• Positive Controls
  • HeLa nuclear extract lysate (ab14655)

Applications

Target

• FunctionPart of the RFX complex that binds to the X-box of MHC II promoters.
• Tissue specificityUbiquitous.
• Involvement in diseaseDefects in RFXAP are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
• Post-translational
  modificationsPhosphorylated.
• Cellular localizationNucleus.

• Target information above from: UniProt accession O00287 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 5994 Human
  • Omim: 601861 Human
  • SwissProt: O00287 Human
  • Unigene: 24422 Human
• Alternative names
  • Regulatory factor X associated protein antibody
  • Regulatory factor X-associated protein antibody
  • RFX associated protein antibody

  • RFX DNA binding complex 36 kDa subunit antibody
  • RFX DNA-binding complex 36 kDa subunit antibody
  • RFX-associated protein antibody
  • RFXAP antibody
  • RFXAP_HUMAN antibody

  see all