Overview

  • Product nameAnti-RGS2 antibody
    See all RGS2 primary antibodies
  • Description
    Chicken polyclonal to RGS2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Amino acids 1-211 human RGS2

Properties

Applications

Our Abpromise guarantee covers the use of ab14069 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 24 kDa.

Target

  • FunctionRegulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
  • Tissue specificityExpressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
  • Sequence similaritiesContains 1 RGS domain.
  • Post-translational
    modifications
    Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
  • Cellular localizationCell membrane. Mitochondrion and Cell membrane. Cytoplasm. Nucleus, nucleolus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Basic helix-loop-helix phosphoprotein G0S8 antibody
    • Cell growth inhibiting protein 31 antibody
    • Cell growth-inhibiting gene 31 protein antibody
    • G0 to G1 switch regulatory 8 24kD antibody
    • G0/G1 switch regulatory protein 8 antibody
    • G0S8 antibody
    • GOS8 antibody
    • OTTHUMP00000060765 antibody
    • Regulator of G protein signaling 2 antibody
    • Regulator of G protein signalling 2 24kD antibody
    • Regulator of G-protein signaling 2 antibody
    • Regulators of G protein signaling XRGSVI antibody
    • RGS 2 antibody
    • RGS2 antibody
    • RGS2_HUMAN antibody
    see all

Anti-RGS2 antibody images



  • Predicted band size : 24 kDa


    Western blot analysis of E coli derived RGS2 fusion protein using ab14069 at 1/2000

References for Anti-RGS2 antibody (ab14069)

ab14069 has not yet been referenced specifically in any publications.

Product Wall

I'm sorry to hear you are having problems with ab14069. I would like to recommend to block for 1 hr with 5% milk and to incubate the primary antibody overnight in TBST at 4C, then wash in TBST several times before applying the secondary antibody. ...

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Thank you for your enquiry. The WB test was done on a recombinant fusion protein. The size is much bigger than the native protein.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"