Overview

  • Product nameAnti-RGS20 antibody
    See all RGS20 primary antibodies
  • Description
    Rabbit polyclonal to RGS20
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 59-108 (NACCFCWCCC CSCSCLTVRN QEDQRPTIAS HELRADLPTW EESPAPTLEE) of Human RGS20 (NP_003693).

  • Positive control
    • COLO205 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab123007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionInhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
  • Tissue specificityIsoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.
  • Sequence similaritiesContains 1 RGS domain.
  • Post-translational
    modifications
    Fatty acylated. Heavily palmitoylated in the cysteine string motif.
    N- and O-glycosylated in synapsomal membranes.
    Serine phosphorylated in synapsomal membranes.
    Sumoylated by SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.
  • Cellular localizationMembrane. Nucleus. Cytoplasm. Shuttles between the cytoplasm/cell membrane and the nucleus (By similarity). Anchored to the membrane through palmitoylation.
  • Information by UniProt
  • Database links
  • Alternative names
    • G(z)GAP antibody
    • Gz selective GTPase activating protein antibody
    • Gz-GAP antibody
    • Gz-selective GTPase-activating protein antibody
    • HGNC:14600 antibody
    • Regulator of G protein signaling 20 antibody
    • Regulator of G-protein signaling 20 antibody
    • Regulator of G-protein signaling Z1 antibody
    • Regulator of Gz selective protein signaling 1 antibody
    • Regulator of Gz-selective protein signaling 1 antibody
    • RGS20 antibody
    • RGS20_HUMAN antibody
    • RGSZ1 antibody
    • ZGAP1 antibody
    see all

Anti-RGS20 antibody images

  • Anti-RGS20 antibody (ab123007) at 1 µg/ml + COLO205 cell lysate at 10 µg

    Predicted band size : 27 kDa

References for Anti-RGS20 antibody (ab123007)

ab123007 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"