Anti-RGS4 antibody [2D3.3] (ab9962)

Overview

  • Product nameAnti-RGS4 antibody [2D3.3]
    See all RGS4 primary antibodies
  • Description
    Armenian Hamster monoclonal [2D3.3] to RGS4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Purified recombinant 6X His-tagged full length human RGS4 protein.

  • EpitopeN-terminus 22 aa.
  • General notesThis antibody was raised in Armenian Hamster.

Properties

Applications

Our Abpromise guarantee covers the use of ab9962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWestern blot: 1/500 block with 3% BSA, 1% non-fat dry milk in TBS-0.1% Tween (Whatman filtered).
  • Target

    • FunctionInhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
    • Involvement in diseaseGenetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
    • Sequence similaritiesContains 1 RGS domain.
    • Post-translational
      modifications
      Palmitoylated on Cys-2 and/or Cys-12.
      Phosphorylated by cyclic GMP-dependent protein kinase.
    • Information by UniProt
    • Database links
    • Alternative names
      • MGC2124 antibody
      • MGC60244 antibody
      • Regulator of G protein signalling 4 antibody
      • Regulator of G-protein signaling 4 antibody
      • RGP 4 antibody
      • RGP4 antibody
      • RGS 4 antibody
      • RGS4 antibody
      • RGS4_HUMAN antibody
      • Schizophrenia disorder 9 antibody
      • SCZD 9 antibody
      • SCZD9 antibody
      see all

    References for Anti-RGS4 antibody [2D3.3] (ab9962)

    ab9962 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your patience, I have only just heard back from the antibody's originator. Ab9962 was raised in an Armenian hamster and will detect a band at 26 kDa. If you have any more questions, please contact us again.

    Thank you for your patience, I have only just heard back from the antibody's originator. Ab9962 was raised in an Armenian hamster. If you have any more questions, please contact us again.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"