Anti-RGS4 antibody [2D3.3] (ab9962)

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Overview

  • Product name
    Anti-RGS4 antibody [2D3.3]
    See all RGS4 primary antibodies
  • Description
    Armenian Hamster monoclonal [2D3.3] to RGS4
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Purified recombinant 6X His-tagged full length human RGS4 protein.

  • Epitope
    N-terminus 22 aa.
  • General notes
    This antibody was raised in Armenian Hamster.

Properties

Applications

Our Abpromise guarantee covers the use of ab9962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    Western blot: 1/500 block with 3% BSA, 1% non-fat dry milk in TBS-0.1% Tween (Whatman filtered).

    • Target

    • Function
      Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
    • Involvement in disease
      Genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
    • Sequence similarities
      Contains 1 RGS domain.
    • Post-translational
      modifications
      Palmitoylated on Cys-2 and/or Cys-12.
      Phosphorylated by cyclic GMP-dependent protein kinase.
    • Information by UniProt
    • Database links
      see all
    • Alternative names
      • MGC2124 antibody
      • MGC60244 antibody
      • Regulator of G protein signalling 4 antibody
      • Regulator of G-protein signaling 4 antibody
      • RGP 4 antibody
      • RGP4 antibody
      • RGS 4 antibody
      • RGS4 antibody
      • RGS4_HUMAN antibody
      • Schizophrenia disorder 9 antibody
      • SCZD 9 antibody
      • SCZD9 antibody
      see all

    References for Anti-RGS4 antibody [2D3.3] (ab9962)

    ab9962 has not yet been referenced specifically in any publications.

    Publishing research using ab9962? Please let us know so that we can cite the reference in this datasheet.

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    2 Abreviews or Q&A

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    Votes: Highest First

    I bought your product 'ab9962 RGS4 antibody [2D3.3] '. I will use it for Western Blotting, but I don't have a secondary antibody. I should prepare an anti-Hamster IgG(HRP). So, I want to know the race of this hamster which was used to raise in. Is it...

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    Thank you for your patience, I have only just heard back from the antibody's originator. Ab9962 was raised in an Armenian hamster and will detect a band at 26 kDa. If you have any more questions, please contact us again.

    Customer would like to know what species of hamster ab9962 was raised in.

    Thank you for your patience, I have only just heard back from the antibody's originator. Ab9962 was raised in an Armenian hamster. If you have any more questions, please contact us again.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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