Overview

  • Product nameAnti-RGS4 antibody
    See all RGS4 primary antibodies
  • Description
    Rabbit polyclonal to RGS4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 253-302 (IFNLMEKDSY RRFLKSRFYL DLVNPSSCGA EKQKGAKSSA DCASLVPQCA) of Human RGS4 (NP_001095915).

  • Positive control
    • HepG2 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab125333 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionInhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
  • Involvement in diseaseGenetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • Sequence similaritiesContains 1 RGS domain.
  • Post-translational
    modifications
    Palmitoylated on Cys-2 and/or Cys-12.
    Phosphorylated by cyclic GMP-dependent protein kinase.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC2124 antibody
    • MGC60244 antibody
    • Regulator of G protein signalling 4 antibody
    • Regulator of G-protein signaling 4 antibody
    • RGP 4 antibody
    • RGP4 antibody
    • RGS 4 antibody
    • RGS4 antibody
    • RGS4_HUMAN antibody
    • Schizophrenia disorder 9 antibody
    • SCZD 9 antibody
    • SCZD9 antibody
    see all

Anti-RGS4 antibody images

  • Anti-RGS4 antibody (ab125333) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 34 kDa

References for Anti-RGS4 antibody (ab125333)

ab125333 has not yet been referenced specifically in any publications.

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