Overview

  • Product name
  • Description
    Rabbit polyclonal to RGS4
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 153-183 of Human RGS4.

  • Positive control
    • MDA-MB231 cell line lysate; Mouse brain tissue lysate; 293 cell lysate transiently transfected with the RGS4 gene.

Properties

Applications

Our Abpromise guarantee covers the use of ab135725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 23 kDa.

Target

  • Function
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
  • Involvement in disease
    Genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • Sequence similarities
    Contains 1 RGS domain.
  • Post-translational
    modifications
    Palmitoylated on Cys-2 and/or Cys-12.
    Phosphorylated by cyclic GMP-dependent protein kinase.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC2124 antibody
    • MGC60244 antibody
    • Regulator of G protein signalling 4 antibody
    • Regulator of G-protein signaling 4 antibody
    • RGP 4 antibody
    • RGP4 antibody
    • RGS 4 antibody
    • RGS4 antibody
    • RGS4_HUMAN antibody
    • Schizophrenia disorder 9 antibody
    • SCZD 9 antibody
    • SCZD9 antibody
    see all

Images

  • Anti-RGS4 antibody (ab135725) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

    Predicted band size : 23 kDa
  • Anti-RGS4 antibody (ab135725) at 1/100 dilution + Mouse brain tissue lysate at 35 µg

    Predicted band size : 23 kDa
  • All lanes : Anti-RGS4 antibody (ab135725) at 1/100 dilution

    Lane 1 : 293 cell lysate, non-transfected
    Lane 2 : 293 cell lysate, transiently transfected with the RGS4 gene

    Lysates/proteins at 2 µg per lane.


    Predicted band size : 23 kDa

References

ab135725 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab135725.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up