Anti-RGS8 antibody (ab14267)

Overview

• Product nameAnti-RGS8 antibody
  See all RGS8 primary antibodies
• Description
  Chicken polyclonal to RGS8
• Tested applicationsSuitable for: WBmore details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Synthetic peptide:

  MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEF

  , corresponding to amino acids 1-85 of Human RGS8.
  Run BLAST with Run BLAST with
• General notes

  
  

  Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein coupled receptor complexes. RGS proteins are GTPase activating proteins for Gi and Gq class G alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. RGS8 is a brain specific RGS protein.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Primary antibody notesRegulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein coupled receptor complexes. RGS proteins are GTPase activating proteins for Gi and Gq class G alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. RGS8 is a brain specific RGS protein.
• ClonalityPolyclonal
• IsotypeIgY
• Research areas
  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Regulators

Applications

Target

• FunctionInhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3.
• Sequence similaritiesContains 1 RGS domain.

• Target information above from: UniProt accession P57771 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 85397 Human
  • Entrez Gene: 67792 Mouse
  • Entrez Gene: 54297 Rat
  • Omim: 607189 Human
  • SwissProt: P57771 Human
  • SwissProt: Q8BXT1 Mouse
  • SwissProt: P49804 Rat
  • Unigene: 20982 Human

  • Unigene: 458417 Human
  • Unigene: 379143 Mouse
  • Unigene: 89634 Rat

  see all
• Alternative names
  • Regulator of G Protein Signalling 8 antibody
  • Regulator of G-protein signaling 8 antibody
  • RGS8 antibody
  • RGS8_HUMAN antibody