Overview

  • Product name
    Anti-RGS9 antibody - C-terminal
    See all RGS9 primary antibodies
  • Description
    Rabbit polyclonal to RGS9 - C-terminal
  • Specificity
    No cross reactivity with other proteins.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human RGS9 aa 624-638 (C terminal).
    Sequence:

    LKSKRVANFFQIKMD


    Database link: O75916

  • Positive control
    • Rat and Mouse Brain Tissue Lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
    Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab191025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 77 kDa.

Target

  • Function
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction.
  • Tissue specificity
    Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).
  • Involvement in disease
    Defects in RGS9 are a cause of prolonged electroretinal response suppression (PERRS) [MIM:608415]; also known as bradyopsia. PERRS is characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.
  • Sequence similarities
    Contains 1 DEP domain.
    Contains 1 G protein gamma domain.
    Contains 1 RGS domain.
  • Domain
    In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments.
  • Post-translational
    modifications
    Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition.
  • Cellular localization
    Membrane. Isoform 3 is targeted to the membrane via its interaction with RGS9BP.
  • Information by UniProt
  • Database links
  • Alternative names
    • PERRS antibody
    • R9AP antibody
    • Regulator of G protein signalling 9 antibody
    • Regulator of G-protein signaling 9 antibody
    • RGS9 antibody
    • RGS9_HUMAN antibody
    • RGS9L antibody
    see all

Images

  • All lanes : Anti-RGS9 antibody - C-terminal (ab191025) at 0.5 µg

    Lane 1 : Rat Brain Tissue Lysate
    Lane 2 : Mouse Brain Tissue Lysate


    Predicted band size : 77 kDa

References

ab191025 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab191025.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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