The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 53 kDa.
FunctionFunctions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
Tissue specificityExpressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney.
Sequence similaritiesBelongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Developmental stageSpecifically expressed in fetal kidney.
Cellular localizationApical cell membrane. Also detected at the basolateral membrane and in subapical vesicles.