Synthetic peptide phosphorylated at Ser188, corresponding to amino acid residues around serine 188 of human RhoA, conjugated to KLH.
Post-translational regulation of Rho activity has been shown specifically for RhoA. This Rho protein is phosphorylated in vitro on serine 188 by cAMP- and cGMP-dependent kinases (PKA and PKG). Ser188 phosphorylation enhances RhoGDI binding and inhibits RhoA-mediated stress fiber formation. Thus, Ser188 is an important site for negative regulation of RhoA activity.
Our Abpromise guarantee covers the use of ab41435 in the following tested applications.
|WB||1/1000. Predicted molecular weight: 22 kDa.|