Overview

  • Product name
  • Description
    Rabbit polyclonal to RHOB
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Chicken, Cow, Pig, Xenopus laevis, Monkey, Xenopus tropicalis
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-146 of Human RHOB (UniProt P62745).

  • Positive control
    • MR32 and U-87 MG cell lysates; Mouse brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab155149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 22 kDa.

Target

  • Function
    Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
  • Sequence similarities
    Belongs to the small GTPase superfamily. Rho family.
  • Post-translational
    modifications
    Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
  • Cellular localization
    Late endosome membrane. Cell membrane. Nucleus. Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aplysia RAS-related homolog 6 antibody
    • ARH6 antibody
    • ARHB antibody
    • H6 antibody
    • MST081 antibody
    • MSTP081 antibody
    • oncogene RHO H6 antibody
    • ras homolog family member B antibody
    • ras homolog gene family, member B antibody
    • Rho cDNA clone 6 antibody
    • Rho related GTP binding protein RhoB Precursor antibody
    • Rho-related GTP-binding protein RhoB antibody
    • Rhob antibody
    • RHOB_HUMAN antibody
    • RHOH6 antibody
    see all

Images

  • Anti-RHOB antibody (ab155149) at 1/500 dilution + U-87 MG whole cell lysate at 30 µg

    Predicted band size : 22 kDa
  • Anti-RHOB antibody (ab155149) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size : 22 kDa

References

ab155149 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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