Overview

  • Product name
  • Description
    Rabbit polyclonal to RIC3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 319-348 of Human RIC3 (NP_001128581.1 , NP_078833.3)

  • Positive control
    • NCI-H292 Cell Lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab112911 was purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG

Applications

Our Abpromise guarantee covers the use of ab112911 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 41 kDa.

Target

  • Function
    Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.
  • Tissue specificity
    Broadly expressed, with high levels in muscle, brain and heart. Over-expressed in brains from patients with bipolar disease or schizophrenia.
  • Sequence similarities
    Belongs to the ric-3 family.
  • Cellular localization
    Endoplasmic reticulum membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AYST720 antibody
    • FLJ11608 antibody
    • PRO1385 antibody
    • Protein RIC-3 antibody
    • Resistance to inhibitors of cholinesterase 3 homolog antibody
    • Resistant to inhibitor of cholinesterase 3 antibody
    • RIC3 acetylcholine receptor chaperone antibody
    • Ric3 antibody
    • RIC3_HUMAN antibody
    see all

Images

  • Anti-RIC3 antibody (ab112911) at 1/100 dilution + NCI-H292 Cell Lysate at 35 µg

    Predicted band size : 41 kDa

References

This product has been referenced in:
  • Mulcahy MJ  et al. Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human a7-Nicotinic Acetylcholine Receptor Interactome. PLoS One 10:e0134409 (2015). WB ; Human . Read more (PubMed: 26258666) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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