Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.
Broadly expressed, with high levels in muscle, brain and heart. Over-expressed in brains from patients with bipolar disease or schizophrenia.
Belongs to the ric-3 family.
Endoplasmic reticulum membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane.
Mulcahy MJ et al. Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human a7-Nicotinic Acetylcholine Receptor Interactome. PLoS One10:e0134409 (2015).
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