Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-KQPIVDTSAES
    • Amino acids1698 to 1708

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-RICTOR antibody (ab32892)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • AVO3
    • AVO3 homolog
    • DKFZp686B11164
    • hAVO3
    • KIAA1999
    • Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae)
    • mAVO3
    • MGC39830
    • PIA
    • Pianissimo
    • Rapamycin insensitive companion of mTOR
    • Rapamycin-insensitive companion of mTOR
    • Rictor
    • RICTR
    • RICTR_HUMAN
    • RPTOR independent companion of MTOR complex 2
    • TORC2 specific protein AVO3
    see all
  • FunctionSubunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
  • Sequence similaritiesBelongs to the RICTOR family.
  • Post-translational
    modifications
    Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
  • Information by UniProt

References for RICTOR peptide (1698-1708) (ab45725)

ab45725 has not yet been referenced specifically in any publications.

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