The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml.
Use at an assay dependent concentration. PubMed: 22825554
FunctionRas effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.
Tissue specificityWidely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood.
Involvement in diseaseDefects in RIN2 are the cause of MACS syndrome (MACS) [MIM:613075]; also called macrocephaly alopecia cutis laxa and scoliosis syndrome. MACS is an autosomal-recessive inherited complex disorder of elastic tissue, characterized by sagging skin and occasionally by life-threatening visceral complications.
Sequence similaritiesBelongs to the RIN (Ras interaction/interference) family. Contains 1 Ras-associating domain. Contains 1 SH2 domain. Contains 1 VPS9 domain.
RAS association (RalGDS/AF-6) domain containing protein JC265 antibody
Ras association domain family 4 antibody
Ras inhibitor JC265 antibody
Ras interaction/interference protein 2 antibody
RIN 2 antibody
Anti-RIN2 antibody images
Western blot - RIN2 antibody (ab57377)
Western blot against tagged recombinant protein immunogen using ab57377 RIN2 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa
References for Anti-RIN2 antibody (ab57377)
This product has been referenced in:
Sandri C et al. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res22:1479-501 (2012).
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