Overview

  • Product nameAnti-RIN2 antibody
    See all RIN2 primary antibodies
  • Description
    Mouse monoclonal to RIN2
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 786-895 of Human RIN2

Properties

Applications

Our Abpromise guarantee covers the use of ab57377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml.
IP Use at an assay dependent concentration. PubMed: 22825554

Target

  • FunctionRas effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.
  • Tissue specificityWidely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood.
  • Involvement in diseaseDefects in RIN2 are the cause of MACS syndrome (MACS) [MIM:613075]; also called macrocephaly alopecia cutis laxa and scoliosis syndrome. MACS is an autosomal-recessive inherited complex disorder of elastic tissue, characterized by sagging skin and occasionally by life-threatening visceral complications.
  • Sequence similaritiesBelongs to the RIN (Ras interaction/interference) family.
    Contains 1 Ras-associating domain.
    Contains 1 SH2 domain.
    Contains 1 VPS9 domain.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • MACS antibody
    • RAB5 interacting protein 2 antibody
    • Ras and Rab interactor 2 antibody
    • RAS association (RalGDS/AF-6) domain containing protein JC265 antibody
    • Ras association domain family 4 antibody
    • Ras inhibitor JC265 antibody
    • Ras interaction/interference protein 2 antibody
    • RASSF4 antibody
    • RIN 2 antibody
    • RIN2 antibody
    • RIN2_HUMAN antibody
    see all

Anti-RIN2 antibody images

  • Western blot against tagged recombinant protein immunogen using ab57377 RIN2 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

References for Anti-RIN2 antibody (ab57377)

This product has been referenced in:
  • Sandri C  et al. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res 22:1479-501 (2012). IP ; Human . Read more (PubMed: 22825554) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"