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Product name Anti-RIP2 antibody See all RIP2 primary antibodies
Rabbit polyclonal to RIP2
Tested applications Suitable for:
WB, ICC/IF more details
Mouse, Rat, Human
KLKDNKQMGLQPYPE , corresponding to amino acids 508-522 of Human RIP2.
(Peptide available as
K562 or 3T3 whole celllysate
An approximately60 kDa band can be detected.
Storage instructions Shipped at 4°C. Store at +4°C.
Storage buffer PBS with 0.02% sodium azide
Concentration information loading...
Purity IgG fraction
Immunizing Peptide (Blocking)
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500. Detects a band of approximately 60 kDa.Can be blocked with
Human RIP2 peptide (ab8462).
Use a concentration of 5 µg/ml.
Function Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.
Tissue specificity Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Sequence similarities Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 1 CARD domain. Contains 1 protein kinase domain.
Post-translational modifications Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination catalyzed by ITCH.
Cellular localization Cytoplasm.
Information by UniProt
CARD 3 antibody
CARD carrying kinase antibody
CARD containing ICE associated kinase antibody
References for Anti-RIP2 antibody (ab8427)
This product has been referenced in:
et al. Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-?B signaling. J Immunol 192:4379-85 (2014).
Read more (PubMed: 24706726) »
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for this product
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"