Overview

  • Product name
  • Description
    Rabbit polyclonal to RITA
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 167-254 of Human RITA (UniProt ID: Q96K30).

  • Positive control
    • Human rectum tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab122531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.

Target

  • Function
    Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
  • Sequence similarities
    Belongs to the RITA family.
  • Cellular localization
    Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome. Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.
  • Information by UniProt
  • Database links
  • Alternative names
    • C12orf52 antibody
    • Chromosome 12 open reading frame 52 antibody
    • RBPJ interacting and tubulin associated 1 antibody
    • RBPJ interacting and tubulin associated protein 1 antibody
    • RBPJ-interacting and tubulin-associated protein antibody
    • RITA antibody
    • RITA_HUMAN antibody
    see all

Images

  • Immunohistochemical staining of RITA in paraffin embedded Human rectum tissue by Immunohistochemistry, using ab122531 at a 1/75 dilution. The image shows cytoplasmic and membranous positivity in glandular cells.

References

ab122531 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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