Anti-RLTPR antibody (ab122717)
Key features and details
- Rabbit polyclonal to RLTPR
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-RLTPR antibody
See all RLTPR primary antibodies -
Description
Rabbit polyclonal to RLTPR -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
antigen sequence: EVNELCQSVQ EHVELLGCGA GPQGEAAVRQ AEDAIQNANF SLSILPILYE AGSSPSHHWQ LGQKLEGLLR QVGEVCRQDI QDFTQ, corresponding to amino acids 729-813 of Human RLTPR.
-
Positive control
- Human rectum tissue
-
General notes
ab122717 is mono-specific.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Primary antibody notes
ab122717 is mono-specific. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab122717 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
Notes |
---|
IHC-P
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
-
Tissue specificity
Expressed in all tissues tested, including thymus, spleen, colon, leukocytes, peripheral blood, skin, skin keratinocytes and skin fibroblasts. -
Sequence similarities
Belongs to the CARMIL family.
Contains 16 LRR (leucine-rich) repeats. -
Developmental stage
Expressed in fetal skin. - Information by UniProt
-
Database links
- Entrez Gene: 146206 Human
- Omim: 610859 Human
- SwissProt: Q6F5E8 Human
- Unigene: 611432 Human
-
Alternative names
- CARMIL2 antibody
- CARMIL2b antibody
- Leucine rich repeat containing 16C antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (5)
ab122717 has been referenced in 5 publications.
- Uchida Y et al. RLTPR Q575E: A novel recurrent gain-of-function mutation in patients with adult T-cell leukemia/lymphoma. Eur J Haematol 106:221-229 (2021). PubMed: 33098696
- Shamriz O et al. Exogenous interleukin-2 can rescue in-vitro T cell activation and proliferation in patients with a novel capping protein regulator and myosin 1 linker 2 mutation. Clin Exp Immunol 200:215-227 (2020). PubMed: 32201938
- Alazami AM et al. Novel CARMIL2 Mutations in Patients with Variable Clinical Dermatitis, Infections, and Combined Immunodeficiency. Front Immunol 9:203 (2018). PubMed: 29479355
- Park J et al. Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E). Blood 130:1430-1440 (2017). PubMed: 28694326
- Schober T et al. A human immunodeficiency syndrome caused by mutations in CARMIL2. Nat Commun 8:14209 (2017). WB ; Human . PubMed: 28112205