Overview

  • Product nameAnti-RNA Helicase A antibody
    See all RNA Helicase A primary antibodies
  • Description
    Rabbit polyclonal to RNA Helicase A
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residues 1220 and the C-terminus (residue 1270) of Human RNA Helicase A (CAA71668.1).

  • Positive control
    • Human stomach adenocarcinoma. Mouse squamous cell carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84499 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionUnwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability.
    • Sequence similaritiesBelongs to the DEAD box helicase family. DEAH subfamily.
      Contains 2 DRBM (double-stranded RNA-binding) domains.
      Contains 1 helicase ATP-binding domain.
      Contains 1 helicase C-terminal domain.
    • DomainThe MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary and sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1.
    • Post-translational
      modifications
      Methylated. HRMT1L2 mediated methylation of undefined Arg residues in the NTD is required for nuclear localization.
      May be phosphorylated by PRKDC/XRCC7. Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus > nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • ATP dependent RNA helicase A antibody
      • ATP-dependent RNA helicase A antibody
      • DDX 9 antibody
      • DDX9 antibody
      • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 9 antibody
      • DEAD/H box 9 antibody
      • DEAD/H box polypeptide 9 antibody
      • DEAH (Asp Glu Ala His) box polypeptide 9 antibody
      • DEAH box polypeptide 9 antibody
      • DEAH box protein 9 antibody
      • DHX 9 antibody
      • dhx9 antibody
      • DHX9_HUMAN antibody
      • Leukophysin antibody
      • LKP antibody
      • NDH 2 antibody
      • NDH II antibody
      • NDH2 antibody
      • NDHII antibody
      • Nuclear DNA helicase II antibody
      • RHA antibody
      see all

    Anti-RNA Helicase A antibody images

    • ab84499, at 1/250 dilution, staining RNA Helicase A in formalin-fixed, paraffin-embedded human stomach adenocarcinoma by Immunohistochemistry, using DAB staining.
    • ab84499, at 1/250 dilution, staining RNA Helicase A in formalin-fixed, paraffin-embedded mouse squamous cell carcinoma by Immunohistochemistry, using DAB staining.

    References for Anti-RNA Helicase A antibody (ab84499)

    ab84499 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab84499.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"