Overview

  • Product nameAnti-RNF12 antibody
    See all RNF12 primary antibodies
  • Description
    Mouse monoclonal to RNF12
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: MENSDSNDKG SGDQSAAQRR SQMDRLDREE AFYQFVNNLS EEDYRLMRDN NLLGTPGEST EEELLRRLQQ IKEGPPPQNS DEN, corresponding to amino acids 1-84 of Human RNF12

Properties

Applications

Our Abpromise guarantee covers the use of ab57230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionE3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
    • Tissue specificityExpressed in many tissues.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesBelongs to the RNF12 family.
      Contains 1 RING-type zinc finger.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • E3 ubiquitin-protein ligase RLIM antibody
      • LIM domain-interacting RING finger protein antibody
      • R-LIM antibody
      • Renal carcinoma antigen NY-REN-43 antibody
      • RING finger LIM domain-binding protein antibody
      • RING finger protein 12 antibody
      • RLIM antibody
      • RNF12 antibody
      • RNF12_HUMAN antibody
      see all

    Anti-RNF12 antibody images



    • Predicted band size : 69 kDa
      RNF12 antibody (ab57230) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-RNF12 antibody (ab57230)

    ab57230 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"