Anti-RNF138/HSD-4 antibody (ab92730)
Key features and details
- Rabbit polyclonal to RNF138/HSD-4
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-RNF138/HSD-4 antibody
See all RNF138/HSD-4 primary antibodies -
Description
Rabbit polyclonal to RNF138/HSD-4 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
Positive control
- WB: MCF7 cell lysate.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine)
Without Mg2+ and Ca2+ -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab92730 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB | (1) |
1/500 - 1/1000. Predicted molecular weight: 28 kDa.
|
Notes |
---|
WB
1/500 - 1/1000. Predicted molecular weight: 28 kDa. |
Target
-
Function
E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. -
Pathway
Protein modification; protein ubiquitination. -
Sequence similarities
Contains 1 RING-type zinc finger. -
Domain
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. -
Post-translational
modificationsAuto-ubiquitinated.
Phosphorylated upon DNA damage, probably by ATM or ATR. - Information by UniProt
-
Database links
- Entrez Gene: 51444 Human
- Entrez Gene: 56515 Mouse
- Entrez Gene: 94196 Rat
- SwissProt: Q8WVD3 Human
- SwissProt: Q9CQE0 Mouse
- SwissProt: Q99PD2 Rat
- Unigene: 302408 Human
- Unigene: 253542 Mouse
see all -
Alternative names
- E3 ubiquitin protein ligase RNF138 antibody
- E3 ubiquitin-protein ligase RNF138 antibody
- hNARF antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (1)
ab92730 has been referenced in 1 publication.
- Fu SJ et al. Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels. J Neurosci 37:2485-2503 (2017). PubMed: 28167673