Overview

  • Product name
  • Description
    Rabbit polyclonal to RNF156
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla
  • Immunogen

    Synthetic peptide corresponding to a region between amino acids 505-555 of Human RNF156 (NP_001135761.1).

  • Positive control
    • HeLa whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab101997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
    • Pathway
      Protein modification; protein ubiquitination.
    • Sequence similarities
      Contains 1 RING-type zinc finger.
    • Domain
      The RING finger is required for ubiquitin ligase activity.
    • Post-translational
      modifications
      Autoubiquitinated in vitro.
    • Cellular localization
      Cytoplasm > cytosol. Cell membrane; Early endosome. The endosomal localization is dependent on the interaction with TSG101 and Cytoplasm > cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
    • Information by UniProt
    • Database links
    • Alternative names
      • E3 ubiquitin-protein ligase MGRN1 antibody
      • KIAA0544 antibody
      • Mahogunin ring finger 1 antibody
      • Mahogunin RING finger protein 1 antibody
      • MGRN 1 antibody
      • Mgrn1 antibody
      • MGRN1_HUMAN antibody
      • Probable E3 ubiquitin protein ligase MGRN1 antibody
      • RING finger protein 156 antibody
      • RNF 156 antibody
      see all

    References

    ab101997 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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