Overview

  • Product nameAnti-RNF168 antibody
    See all RNF168 primary antibodies
  • Description
    Rabbit polyclonal to RNF168
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human RNF168 (NP_689830.2; amino acids 1-571).

  • Positive control
    • Human liver lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab103491 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 65 kDa.

Target

  • FunctionE3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1.
  • PathwayProtein modification; protein ubiquitination.
  • Involvement in diseaseDefects in RNF168 are the cause of Riddle syndrome (RIDDLES) [MIM:611943]. Riddle syndrome is characterized by increased radiosensitivity, immunodeficiency, mild motor control and learning difficulties, facial dysmorphism, and short stature. Defects are probably due to impaired localization of TP53BP1 and BRCA1 at DNA lesions.
  • Sequence similaritiesBelongs to the RNF168 family.
    Contains 1 RING-type zinc finger.
  • DomainThe MIU motifs (motif interacting with ubiquitin) mediate the interaction with ubiquitin and the localization at sites of DNA damage.
  • Cellular localizationNucleus. Localizes to sites of DNA damage.
  • Information by UniProt
  • Database links
  • Alternative names
    • E3 ubiquitin protein ligase RNF168 antibody
    • E3 ubiquitin-protein ligase RNF168 antibody
    • FLJ35794 antibody
    • FLJ39749 antibody
    • RING finger protein 168 antibody
    • RN168_HUMAN antibody
    • RNF 168 antibody
    • Rnf168 antibody
    see all

Anti-RNF168 antibody images

  • Anti-RNF168 antibody (ab103491) at 5 µg/ml + Human liver lysate at 50 µg

    Predicted band size : 65 kDa

References for Anti-RNF168 antibody (ab103491)

ab103491 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"