Overview

  • Product name
  • Description
    Rabbit polyclonal to RNF19B
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 376-405 of Human RNF19B (NP_001120833.1, NP_699172.2)

  • Positive control
    • MCF-7 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab108045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 78 kDa.

Target

  • Function
    E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
  • Tissue specificity
    Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells. Present in natural killer cells (at protein level).
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the RBR family. RNF19 subfamily.
    Contains 1 IBR-type zinc finger.
    Contains 2 RING-type zinc fingers.
  • Domain
    The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1.
  • Cellular localization
    Cytoplasmic granule membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • E3 ubiquitin-protein ligase RNF19B antibody
    • FLJ90005 antibody
    • IBR domain containing 3 antibody
    • IBR domain-containing protein 3 antibody
    • IBRDC3 antibody
    • Natural killer lytic-associated molecule antibody
    • NKLAM antibody
    • RING finger protein 19B antibody
    • RN19B_HUMAN antibody
    • rnf19b antibody
    see all

Images

  • Anti-RNF19B antibody (ab108045) at 1/100 dilution + MCF-7 cell lysate at 35 µg

    Predicted band size : 78 kDa

References

ab108045 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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