Overview

  • Product nameAnti-RNF40 antibody
    See all RNF40 primary antibodies
  • Description
    Rabbit polyclonal to RNF40
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to a region between residues 540 and 590 of human RNF40 (NP_055586.1)

  • Positive control
    • Human mucinous ovarian carcinoma and human prostate adenocarcinoma tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab84515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionE3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBE2E1/UBCH6. It thereby plays a central role in histone code and gene regulation. Required for transcriptional activation of Hox genes.
    • Tissue specificityUbiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesBelongs to the BRE1 family.
      Contains 1 RING-type zinc finger.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 95 kDa retinoblastoma associated protein antibody
      • 95 kDa retinoblastoma protein binding protein antibody
      • 95 kDa retinoblastoma-associated protein antibody
      • BRE 1B antibody
      • BRE1 B antibody
      • BRE1 E3 ubiquitin ligase homolog B antibody
      • BRE1-B antibody
      • BRE1B antibody
      • BRE1B_HUMAN antibody
      • DKFZp686K191 antibody
      • E3 ubiquitin protein ligase BRE1B antibody
      • E3 ubiquitin-protein ligase BRE1B antibody
      • KIAA0661 antibody
      • MGC13051 antibody
      • Rb associated protein antibody
      • RBP 95 antibody
      • RBP95 antibody
      • RING finger protein 40 antibody
      • Ring finger protein 40 E3 ubiquitin protein ligase antibody
      • RNF 40 antibody
      • Rnf40 antibody
      • STARING antibody
      see all

    Anti-RNF40 antibody images

    • ab84515 at 1/250 dilution staining RNF40 in human mucinous ovarian carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84515 at 1/250 dilution staining RNF40 in human prostate adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    References for Anti-RNF40 antibody (ab84515)

    ab84515 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"