Overview

  • Product nameAnti-RNF41 antibody
    See all RNF41 primary antibodies
  • Description
    Rabbit polyclonal to RNF41
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human RNF41 protein (NP_005776.1).

  • Positive control
    • Human kidney tissue lysate; RNF41 transfected 293T cell line lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab103634 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 36 kDa.

Target

  • FunctionActs as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.
  • Tissue specificityDetected in ovary, testis and prostate.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesContains 1 RING-type zinc finger.
    Contains 1 SIAH-type zinc finger.
  • Post-translational
    modifications
    Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4930511A05Rik antibody
    • 4933415P08Rik antibody
    • E3 ubiquitin protein ligase NRDP1 antibody
    • E3 ubiquitin-protein ligase NRDP1 antibody
    • Fetal Liver RING finger protein antibody
    • FLRF antibody
    • MGC45228 antibody
    • Neuregulin receptor degradation protein 1 antibody
    • NRDP1 antibody
    • RING finger protein 41 antibody
    • rnf41 antibody
    • RNF41_HUMAN antibody
    • SBBI03 antibody
    see all

Anti-RNF41 antibody images

  • Anti-RNF41 antibody (ab103634) at 1/500 dilution + Human kidney tissue lysate at 50 µg

    Predicted band size : 36 kDa
  • All lanes : Anti-RNF41 antibody (ab103634) at 1/500 dilution

    Lane 1 : RNF41 transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 36 kDa

References for Anti-RNF41 antibody (ab103634)

ab103634 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab103634.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"