Overview

  • Product name
  • Description
    Rabbit polyclonal to RNF41
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal residues 275 - 317 of Human RNF41 (NP_005776.1). Note: the amino acid sequence is considered to be commercially sensitive.

  • Positive control
    • Prostate adenocarcinoma or metastatic lymph node.

Properties

Applications

Our Abpromise guarantee covers the use of ab84409 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer will enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.
    • Tissue specificity
      Detected in ovary, testis and prostate.
    • Pathway
      Protein modification; protein ubiquitination.
    • Sequence similarities
      Contains 1 RING-type zinc finger.
      Contains 1 SIAH-type zinc finger.
    • Post-translational
      modifications
      Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.
    • Information by UniProt
    • Database links
    • Alternative names
      • 4930511A05Rik antibody
      • 4933415P08Rik antibody
      • E3 ubiquitin protein ligase NRDP1 antibody
      • E3 ubiquitin-protein ligase NRDP1 antibody
      • Fetal Liver RING finger protein antibody
      • FLRF antibody
      • MGC45228 antibody
      • Neuregulin receptor degradation protein 1 antibody
      • NRDP1 antibody
      • RING finger protein 41 antibody
      • rnf41 antibody
      • RNF41_HUMAN antibody
      • SBBI03 antibody
      see all

    Images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate adenocarcinoma, using 1/250 ab84409 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human metastatic lymph node, using 1/250 ab84409 followed by DAB staining.

    References

    ab84409 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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