Overview

  • Product nameAnti-RNF6 antibody
    See all RNF6 primary antibodies
  • Description
    Mouse monoclonal to RNF6
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE DYRLMRDHNL LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV , corresponding to amino acids 1-101 of Human RNF6

Properties

Applications

Our Abpromise guarantee covers the use of ab58293 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionE3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
    • Tissue specificityWeakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
    • PathwayProtein modification; protein ubiquitination.
    • Involvement in diseaseDefects in RNF6 may be a cause of esophageal cancer (ESCR) [MIM:133239]. A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
    • Sequence similaritiesBelongs to the RNF12 family.
      Contains 1 RING-type zinc finger.
    • Developmental stageExpressed in embryo and adult testis.
    • Cellular localizationNucleus. Cytoplasm. Cell projection > axon. Nucleus > PML body. Localizes to the PML nuclear bodies in Sertoli cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • E3 ubiquitin-protein ligase RNF6 antibody
      • Ring finger protein (C3H2C3 type) 6 antibody
      • Ring finger protein 6 antibody
      • RING H2 protein antibody
      • RING H2 protein RNF6 antibody
      • RNF 6 antibody
      • RNF6 antibody
      • RNF6_HUMAN antibody
      • SPG2 antibody
      see all

    Anti-RNF6 antibody images

    • Western blot against tagged recombinant protein immunogen using ab58293 RNF6 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-RNF6 antibody (ab58293)

    ab58293 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"